Nanoscience at Duke: nano-Duke
(Jan. 2000)
Overview
The astounding changes in our world that have resulted from the widespread
use of computers, lasers, and novel materials represent only the early
stages of a radical transformation of our material culture. The future
holds the promise of tiny sensors and computers embedded in everyday objects,
interfaces between physical devices and biological systems at the cellular
and molecular level, lightweight materials with unprecedented strength,
and tiny machines that operate on sub-cellular scales. These will have
profound effects on everyday life as well as on physical sciences, biological
sciences and engineering disciplines. All of this will be made possible
by coordinated advances in the emerging interdisciplinary field called
``Nanoscience'',
the science of physical systems about a billionth of a meter (a ``nanometer'')
in size. To quote NSF Assistant Director Eugene Wong, the nanometer is
a ``magical point on the scale of length, for this is the point where the
smallest man-made devices meet the atoms and molecules of the natural world.''
Nanoscience: A Field in Transition
Nanoscience is a field in transition. The study of small bits of solid
is, of course, not new. But a set of systems and problems has been extensively
studied: the properties of electrons in structures made by physical lithography.
Currently, the field is greatly expanding its view as it turns to other
issues, notably ones motivated by biology, and other kinds of nanostructures.
The field has begun to blossom rapidly for two reasons. First, spectacularly
precise and versatile probes have recently been developed. Instruments
such as the atomic force microscope and scanning tunneling microscope can
directly observe the arrangements of individual atoms on a surface. They
can be used to probe reversibly the folding of proteins. And they are essential
for accurately characterizing nanostructures used in many domains, from
biomedical engineering to physics. Second, the rapid development of new
growth and synthesis techniques for the creation of nanostructures, such
as quantum dot growth by self-assembly, is opening up fundamentally new
types of structures. The field is poised for rapid growth in the foreseeable
future, as new nanostructure materials are developed and as nanostructuring
processes are applied to existing inorganic, organic, and hybrid materials.
The Breadth of Nanoscience
Perhaps the best way to indicate the scope of Nanoscience is to briefly
summarize some of the current work in the area here at Duke in various
departments.
Physics-- Nanophysics probes the interface between the quantum
micro world and the classical macro world. On the one hand, new phenomena
occur which require new concepts: novel many-body states in quantum wires
and dots, for instance. On the other hand, the microscopic basis for bulk
phenomena can be probed: exploring friction by pushing a single atom tip
along an atomically flat surface is a recent example. The primary current
focus of Nanophysics is on many-body phenomena in low-dimensional systems.
Future topics include, for instance, transport through single molecules,
magnetic nanoparticles, dissipation in quantum systems and quantum computing,
the interplay of nanosystems with membranes and supramolecular structures,
and optical properties of nanostructured materials. [Baranger
and Matveev (theory), Finkelstein
(experiment)]
Chemistry-- Nanochemistry focuses on the preparation and manipulation
of materials with nanometer scale dimensions. Materials of this size often
exhibit unique chemical properties which promise to be important for technological
applications. For example, it is known that carbon nanotubes can be either
metallic or semiconductive depending on their diameter and atomic orientation.
This richness in electronic properties makes carbon nanotubes ideal candidates
for interconnections and even functional devices in molecular electronics.
Current research in the Chemistry department includes probing the formation
mechanisms of carbon nanotubes and nanoparticles, manipulating individual
nano-objects through chemically guided assembly, and using AFM lithography
to assemble biological macromolecules. These approaches will allow us to
design and synthesize nanostructures in pre-designed patterns to form functional
nanodevices and nanobiosensors. [Liu]
Computer Science-- The possibility of using DNA to fabricate
nanoscale computational elements of several sorts is being investigated
theoretically and experimentally. Due to its easily programmable molecular
association rules (base pairing) and the vast infrastructure developed
for molecular biology, DNA is attractive for bottom-up construction of
nano-scale objects and devices. Specifically designed DNA molecules are
able to self-assemble into complex structural components which, in turn,
associate specifically with neighboring components to form superstructures.
Sets of DNA molecules can be designed to form only superstructures which
represent valid solutions to computational problems (for example, n-bit
addition). Other sets of DNA have been used to form structures which self-assemble
into micron-scale, periodic lattices with nano-scale feature precision.
Currently, we are optimizing known chemical protocols to ``grow'' nano-scale
gold wires using self-assembled DNA lattices as templates. Similarly, self-assembled
DNA structures are being used as frameworks upon which to immobilize electrically
active organic chemicals in an attempt to construct molecular-scale circuitry.
[LaBean and Reif]
Bio-Medical Engineering-- Biology works to a large extent
on the nanometer scale. With advances in the ability to characterize and
create molecular constructs, and to genetically control protein structure/function,
researchers are now engineering biology at the molecular level. Several
technical hurdles remain: for both multi-analyte biosenseing and biomaterials,
for example, site-specific immobilization of biomacromolecules at the nanometer
scale is needed. In fact, the era of bioactive biomaterials has emerged
through greater understanding of the molecular events of wound healing,
cell adhesion, and ligand binding. In tissue engineering, for example,
it is desired to have cells bind to degradable polymeric scaffolds so that
they will grow into organized, functionally distinct tissues. This requires
knowledge of matrix-cellular signaling that encourages the directed growth
and differentiation of cells. One strategy is to identify the density and
composition of extra-cellular matrix proteins that lead to tissue growth,
and reproduce this pattern through nanometer scale immobilization, which
in turn requires nanoscale patterning. [Chilkoti
and Reichert]
Electrical Engineering-- A variety of nanostructures are readily
prepared with the group III-V compound semiconductors by molecular-beam
epitaxy (MBE) or metal-organic chemical vapor deposition (MOCVD). These
structures have tens of nanometers dimensions as quantum wells or quantum
dots. Because these structures are prepared as readily controlled layers
within cladding layers of similar semiconductors, subsequent nanometer
patterning is not required. Many properties of these quantum structures
may be investigated with ultra-fast laser excitation; our present measurements
use differential transmission of sub 100 fs pulses to probe the carrier
dynamics in these nanostructures. Many issues remain to be resolved concerning
the behavior of quantum wells and dots, and it is currently a very active
research area. [Casey, Everitt,
and Teitsworth]
Materials Science-- A Nanoscience program in the general area
of ``Biological and other Soft Wet Materials'' focuses on coating and encapsulation
of particles in the colloidal size range (10 nanometers to 10 micrometers).
It essentially comprises two related areas. One deals with the material
properties of lipid monolayers, bilayer membranes, hydrogels, emulsions,
and cells. And the other is concerned with adhesion and repulsion involving
molecular structures at interfaces, including water-soluble polymers and
receptor-mediated cell adhesion. Two focuses of current research are molecular
exchange and defect formation in lipid vesicle membranes, and the measurement
of the local compliance of cellular interfaces and bond strengths for receptor-ligand
bonds in response to cell activation. Information gained in this work is
directed towards improved image contrast agents and drug delivery systems
that use lipids and polymers to create micro- and nano-capsules and monolayer
coatings. These systems are being tested pre-clinically with collaborators
in the Duke Medical Center. [Needham]
Cell Biology-- As stated above, biology works primarily at the
nanometer scale. For example, protein motor molecules move along microtubules
and actin filaments in 1-10 nm steps. Methodology is in place to track
the forces generated for this movement. On another scale, atomic force
microscopy has recently been developed to unfold single proteins by mechanical
stretching, relating the piconewton force to the energy and kinetics of
unfolding. These technologies are ready for exploitation in further understanding
biophysics at the nanometer level, and perhaps for exploitation in nanomachines.
An important expertise in the Cell Biology department is electron microscopy
(EM). At present it is used primarily for imaging cells and single protein
molecules at a 1-2 nm resolution. EM structural analysis continues to be
important in characterizing new proteins, and should be an invaluable resource
in development of arrays or nanomachines. [Erickson]
Last
modified: 11-Aug-00